Protein Variants | Comment | Organism |
---|---|---|
H305P | the mutation is associated with micronodular adrenocortical disease | Mus musculus |
H305P | the mutation is associated with micronodular adrenocortical disease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | O95263 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | axillae | Mus musculus | - |
adrenal cortex | - |
Mus musculus | - |
adrenal cortex | - |
Homo sapiens | - |
adrenal cortex | of newborn mice | Mus musculus | - |
adrenal cortex | tumor tissues from patients with isolated micronodular adrenocortical disease and no mutations in the coding PDE8B sequence or any other related genes (PRKAR1A, PDE11A) show downregulated PDE8B expression compared to normal adrenal cortex. PDE8B is a PDE gene linked to isolated micronodular adrenocortical disease. It is a candidate causative gene for other adrenocortical lesions linked to the cAMP signaling pathway and possibly for tumors in other tissues | Homo sapiens | - |
adrenal gland | - |
Mus musculus | - |
adrenal gland | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | weak activity | Mus musculus | - |
skeletal muscle | weak activity | Mus musculus | - |
testis | weak activity | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Mus musculus | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP-specific phosphodiesterase | - |
Mus musculus |
cAMP-specific phosphodiesterase | - |
Homo sapiens |
PDE8B | - |
Mus musculus |
PDE8B | - |
Homo sapiens |